Stochastic modulation evidences a transitory EGF-Ras-ERK MAPK activity induced by PRMT5

The extracellular signal-regulated kinase (ERK) mitogen-activated protein (MAPK) pathway involves a three-step cascade of kinases that transduce signals and promote processes such as cell growth, development, apoptosis. An aberrant response this is related to the proliferation diseases tumors. By using simulation modeling, we document arginine methyltransferase 5 (PRMT5) modulates MAPK thus avoids an behavior. PRMT5 methylates Raf kinase, reducing its catalytic activity thereby, activation ERK in time amplitude. Two minimal computational models epidermal growth factor (EGF)-Ras-ERK influenced by were proposed: first model which activated EGF second one stimulated response. reported results show reduces duration expression both cases, but only limits range generates activation. Based on our data, propose regulatory develop strategies fight against excessive pathway, could be use chronic cancer.